Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
urine | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
HUK | - |
Homo sapiens |
urinary kallidinogenase | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | HUK reduces brain damage in experimental stroke: in a mouse middle cerebral artery occlusion model, HUK significantly improves neurofunction, decreases infarct size, and suppresses edema, as well as inflammatory mediators as compared with the vehicle group. Furthermore, HUK inhibits the NF-kappaB pathway and activates the MAPK/ERK pathway in this neuroprotection | Homo sapiens |